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| Champion | Won | Lost | Days |
|---|---|---|---|
| René Santiago | 13 Mar 2025 | Current | 586 |
| Shokichi Iwata | 13 Oct 2024 | 13 Mar 2025 | 151 |
| Elwin Soto | 21 Jun 2019 | 16 Oct 2021 | 848 |
| Ángel Acosta | 2 Dec 2017 | 21 Jun 2019 | 566 |
| Kosei Tanaka | 31 Dec 2016 | 30 Nov 2017 | 334 |
| Donnie Nietes | 8 Oct 2011 | 3 Aug 2016 | 1,761 |
| Giovani Segura | 28 Aug 2010 | 22 Apr 2011 | 237 |
| Iván Calderón | 25 Aug 2007 | 28 Aug 2010 | 1,099 |
| Hugo Cázares | 30 Apr 2005 | 25 Aug 2007 | 847 |
| Nelson Dieppa | 14 Apr 2001 | 30 Apr 2005 | 1,477 |
| Jorge Arce | 5 Dec 1998 | 31 Jul 1999 | 238 |
| Melchor Cob Castro | 25 Aug 1997 | 17 Jan 1998 | 145 |
| Paul Weir | 23 Nov 1994 | 18 Nov 1995 | 360 |
| Josué Camacho | 31 Jul 1992 | 15 Jul 1994 | 714 |
Built from title bouts on record. Vacated or stripped titles are not visible in bout results, so very recent changes can lag.